linus pauling vitamin c, lysine protocol

An intervention trial in 75 adult male smokers found that supplementation with 1,000 mg/day of vitamin C resulted in significantly lower blood lead concentration over a four-week treatment period compared to placebo(184). Liu C, Russell RM. Cardiovasc Res. PDF Chapter 7 The Pauling Therapy - Practicing Medicine Without A License Linus Pauling Recommendations 1. In addition, hypovitaminosis C is common in critically ill patients, especially in those with septic shock, and persists despite enteral/parenteral nutritional therapy providing recommended amounts of vitamin C (152). Available at: https://naturalmedicines.therapeuticresearch.com. An analysis that combined data from three, large, independent prospective cohorts, (1) Nurses Health Study 1 (NHS1; 88,540 women, median age 49 years); (2) Nurses Health Study 2 (NHS2; 97,315 women, median age 36 years); and (3) Health Professionals Follow-up Study (HPFS; 37,375 men, median age 52 years), found no association between the level of vitamin C intake and risk of developing hypertension (40). Sodium ascorbate and calcium ascorbate are the most common forms, although a number of other mineral ascorbates are available. Recent Advances in Primary and Secondary Prevention of Atherosclerotic Stroke. (PubMed), 49. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. The recommended dietary calcium intake for adults is 1,000 to 1,200 mg/day. *Monooxygenases catalyze the hydroxylation of one substrate, whereas dioxygenases catalyze a reaction that couples the hydroxylation of a specific substrate with the conversion (decarboxylation) of -ketoglutarate into succinate. Antioxid Redox Signal. 2014;12:32. Curhan GC, Willett WC, Speizer FE, Stampfer MJ. Auer BL, Auer D, Rodgers AL. A much larger study of 19,578 people, including 4,214 children from 6 to 16 years of age, found higher serum vitamin C concentrations to be associated with significantly lower blood lead concentrations (182). Vitamin C is concentrated in the brain through a combination of active transport into brain tissue and retention via the blood-brain barrier (100). Liability for individual actions or omissions based upon the contents of this site is expressly disclaimed. 178. Dr. Pauling significantly increased his recommendation in his 1986 book How To Live Longer and Feel Better. (PubMed), 11. It is not known whether supplemental vitamin C could improve markers of glycemic control in subjects at risk of diabetes. Alzheimer's Association. (PubMed), 168. These enzymes are either monooxygenases or dioxygenases (see Table 1). Pocobelli G, Peters U, Kristal AR, White E. Use of supplements of multivitamins, vitamin C, and vitamin E in relation to mortality. Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. 2010;21(11):1745-1757. See also the section on Sepsis in the Symposium on Vitamin CPart of the LPIs 9th International Conference on Diet and Optimum Health. Sesso HD, Buring JE, Christen WG, et al. PHS II found that vitamin C supplementation (500 mg/day) for an average of eight years had no significant effect on major cardiovascular events, total myocardial infarction, or cardiovascular mortality (53). Jane Higdon, Ph.D. 2011;63(10):3136-3141. PDR for Nutritional Supplements. (PubMed), 45. The effect of ascorbic acid ingestion on the biochemical and physicochemical risk factors associated with calcium oxalate kidney stone formation. Davis JL, Paris HL, Beals JW, et al. Cigarette smoking or second-hand exposure to cigarette smoke contributes to increased blood lead concentration and a state of chronic low-level lead exposure. Mathew MC, Ervin AM, Tao J, Davis RM. Three Arterial Cleansing Regimens - Knowledge of Health The European Investigation into Cancer and Nutrition (EPIC)-Norfolk prospective cohort study investigated the relationship between vitamin C status and incident heart failure in healthy adults (9,187 men and 11,112 women, aged 58.1+/-9.2 years) (49). Lower vitamin C concentrations in the cerebrospinal fluid (CSF) and brain extracellular matrix of a mouse model of AD were found to increase oxidative stress and accelerate amyloid deposition and disease progression (98). Wei L, Liang G, Cai C, Lv J. (PubMed), 47. Atrial fibrillation:Atrial fibrillation is the most common type of cardiac arrhythmia. J Emerg Med. Although CSF vitamin C is maintained at concentrations several-fold higher than plasma vitamin C, the precise function of vitamin C in cognitive function and AD etiology is not yet fully understood (102). 2002;56(1):53-56. Administration of a 1-gram (g) vitamin C infusion one hour prior to the angioplasty reduced the concentrations of oxidative stress markers and improved microcirculatory perfusion compared to placebo (130). Schleicher RL, Carroll MD, Ford ES, Lacher DA. Vitamin C is the primary water-soluble, non-enzymatic antioxidant in plasma and tissues. (PubMed), 204. (PubMed), 43. Proc Natl Acad Sci U S A. 2008;7:35. (PubMed), 96. 2014;15:192. A 2012 review of nine randomized controlled trials found no substantial effect of -carotene, vitamin C, and vitamin E, administered individually or in combination over 2.1 to 12 years, on the risk of cataracts or cataract surgery (112). Authors' perspective: What is the optimum intake of vitamin C in humans? Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease. Potential mechanisms of action for vitamin C in cancer: reviewing the evidence. Levine M, Padayatty SJ, Espey MG. Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Vitamin C (L-ascorbic acid) is available in many forms, but there is little scientific evidence that any one form is better absorbed or more effective than another. 2014;28(2):252-268. If you are not getting enough Vitamin C to produce collagen for tissue repair, when your arteries become injured they cannot heal properly. Years later, Dr. Linus Pauling, two-time Nobel Prize winner, is ignored for reporting that large amounts of vitamin C and lysine are needed to prevent coronary attacks. Vitamin C. In: Erdman JWJ, Macdonald IA, Zeisel SH, eds. Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort. For a more detailed discussion on the bioavailability of different forms of vitamin C, see the article,The Bioavailability of Different Forms of Vitamin C. Severe vitamin C deficiency has been known for many centuries as the potentially fatal disease, scurvy. (PubMed). Two large prospective cohort studies, one following 45,251 men for six years and the other following 85,557 women for 14 years, reported that consumption of 1,500 mg of vitamin C daily did not increase the risk of kidney stone formation compared to those consuming <250 mg daily (196, 197). 2014;53(5):1255-1262. Three meta-analyses of prospective cohort studies and randomized controlled trials have reported an overall reduction in the risk of post-operative atrial fibrillation following administration of primarily oral vitamin C (140-142). The history of these products might make the reasons for (and differences in them) easier to understand. Gastric Cancer. Hemila H, Suonsyrja T. Vitamin C for preventing atrial fibrillation in high risk patients: a systematic review and meta-analysis. (PubMed), 128. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Vitamin C and Cardiovascular Disease - orthomolecular.org Cochrane Database Syst Rev. A new recommended dietary allowance of vitamin C for healthy young women. 10th ed. PLoS One. Vitamin C (L-ascorbic acid) is a potent reducing agent, meaning that it readily donates electrons to recipient molecules ( Figure 1 ). Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials. Most (~80%) cerebrovascular events in high-income countries are ischemic in nature and associated with atherosclerosis as an underlying condition (55, 56). (PubMed), 133. (PubMed), 140. In response to increasing oral doses of vitamin C, plasma vitamin C concentration rises steeply at intakes between 30 and 100 mg/day. 2013;33:45-70. Goodman M, Bostick RM, Kucuk O, Jones DP. 2018;148(3):419-426. The national study identified smokers and those of lower socioeconomic status to both be at higher risk for vitamin C deficiency (36). Although intravenous vitamin C administration appears to be safe and well tolerated, there is a non-negligible risk of oxalate nephropathy (a rare cause of kidney failure) in these critically ill patients (157). Smoking and respiratory conditions in pregnancy: associations with adverse pregnancy outcomes. Oncogene. BMC Ophthalmol. The Normative Aging Study. (PubMed), 40. The relation between gastric vitamin C concentrations, mucosal histology, and CagA seropositivity in the human stomach. 2005;102(38):13604-13609. Gerontology. Leuk Lymphoma. 2005;4:5. Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded, randomized, controlled study. 1996;173(6):1502-1505. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. (PubMed), 125. The Pauling therapy is a combination of the specific orthomolecular nutrients - ascorbic acid, lysine and proline - that are proven to combat coronary heart disease at the specific dosages recommended by Linus Pauling. However, no difference in the infarct size between antioxidant vitamin treatment and placebo was seen (138). Thus, the Linus Pauling Institute recommends a vitamin C intake of 400 mg daily for adults to ensure replete tissue concentrations (29)an amount substantially higher than the RDA yet with minimal risk of side effects. The information is made available with the understanding that the author and publisher are not providing medical, psychological, or nutritional counseling services on this site. Alterations in the structure and function of the vascular endothelium that lines the inner surface of all blood vessels are associated with the loss of normal nitric oxide-mediated endothelium-dependent vasodilation. Zhang S, Hunter DJ, Forman MR, et al. Since the antioxidants were taken together in this trial, the individual contribution of vitamin C cannot be determined. 2013;1(5):e239-240. Pauling Therapy Store - Inteligent*Vitamin*C 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Periprocedural myocardial injury that occurs in up to one-third of patients undergoing otherwise uncomplicated angioplasty increases the risk of morbidity and mortality at follow-up. How long should I expect Linus Pauling's protocol to - Vitamin C Forum 66 auditorium with a talk on Vitamin C and Heart Disease. The MRC/BHF Heart Protection Study: preliminary results. Linus Pauling Heart Disease Prevention with Vitamin C Cell Death Dis. Prospective cohort studies can examine the incidence of a specific disease in relation to vitamin C intake or body status in a cohort of participants who are followed over time. Yet, plasma concentrations of vitamin C 50 mol/L are sufficient to saturate muscle tissue vitamin C. There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27). New England Journal of Medicine 302:694, 1980. In vitro experiments performed using 11 different cancer cell lines demonstrated that sensitivity to vitamin C correlated with the expression of catalase, an enzyme involved in the decomposition of hydrogen peroxide (172). Nutr J. Am J Clin Nutr. Disparate results are likely due to study design issues, often linked to a lack of understanding of vitamin C pharmacokinetics and requirements (19, 20). To get the best results here, I recommend Cardio-C from the Vitamin C Foundation. 2013;97(4):800-807. A 2011 meta-analysis of 13 randomized controlled trials in healthy individuals with elevated serum uric acid revealed that vitamin C supplementation (a median dose of 500 mg/day for a median duration of 30 days) modestly reduced serum uric acid concentrations by 0.35 mg/dL compared to placebo(120). After 14 years of follow-up, it was found that men who consumed 1,000 mg/day of vitamin C had a 41% higher risk of kidney stones compared to men consuming <90 mg of vitamin C daily. Linus Pauling Institute Oregon State University, Reviewed in December 2018 by: Nutrients. (PubMed), 92. 2009;29(3):809-815. Krajewska B, Brindell M. Urease activity and L-ascorbic acid. Michels AJ, Frei B. Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research. Stability of vitamin C derivatives in solution and topical formulations. Nutr Metab Insights. (PubMed), 62. (PubMed), 207. 2016;6(2):243-250. (PubMed), 80. Int J Cancer. Vitamin C supplementation for the primary prevention of cardiovascular disease. PDF How do I know the Pauling Therapy is working and how long will it take? It is produced as a protection mechanism by our bodies to protect us from bleeding out from damaged arteries, caused by a vitamin C deficiency and intrinsically low-level scurvy. 2012;52(9):815-829. In this case, vitamin C is esterified to the saturated fatty acid, palmitic acid, resulting in a fat-soluble form of vitamin C. Ascorbyl palmitate has been added to a number of skin creams due to interest in its antioxidant properties, as well as its importance in collagen synthesis (see the separate article, Vitamin C and Skin Health) (188). Each of the cohort studies used self-administered food frequency questionnaires at baseline to assess vitamin C intake. A 2013 meta-analysis of 17 prospective cohort studies reported a 19% lower risk of stroke with the highest versus lowest dietary vitamin C intakes and a 38% lower risk with the highest versus lowest circulating vitamin C concentrations (59). Zheng Z, Harman JL, Coresh J, et al. Cholesterol and the Linus Pauling Therapy - healingwell.com Br J Anaesth. Arthritis Res Ther. (PubMed), 186. Zhang ZW, Patchett SE, Perrett D, Katelaris PH, Domizio P, Farthing MJ. Ye Z, Song H. Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies. Basically, it's high Vitamin C doses, accompanied by high L-Lysine, L-Proline. Vitamin C has been shown to increase interferon production in vitro(17). Oregon State University, Updated in September 2009 by: Additional detail is provided below for those cancer subtypes with substantial scientific information obtained from prospective cohort studies. Association between plasma vitamin C concentrations and blood pressure in the European prospective investigation into cancer-Norfolk population-based study. (PubMed), 153. The Linus Pauling Institute's Micronutrient Information Center provides scientific information on the health aspects of dietary factors and supplements, food, and beverages for the general public. Vitamin C also participates in redox recycling of other important antioxidants; for example, vitamin C is known to regenerate vitamin E from its oxidized form (see the article on Vitamin E). The other trial randomized subjects diagnosed with infection-related asthma to receive 5 g/day of vitamin C or a placebo for one week; a lower proportion of participants was found to present with bronchial hypersensitivity to histaminewhich characterizes chronic asthmain the vitamin C group compared to the control group (reviewed in 179). 2018;22(1):70. Oregon State University, Updated in November 2002 by: Vitamin C treatment substantially reduced the incidence of periprocedural myocardial injury, as assessed by a reduction in the concentrations of two markers of myocardial injury, namely creatine kinase and troponin-I (131). In the Vitamins and Lifestyle Study, 77,719men and women (ages 50-76 years) were questioned at baseline on their use of dietary supplements during the previous 10 years (124). (PubMed), 50. Hemorrhagic stroke occurs when a weakened blood vessel ruptures and bleeds into the surrounding brain tissue. Linus Pauling's Recommendations for Vitamin C and Lysine - The Ezekiel Diet Files Linus Pauling's Recommendations for Vitamin C and Lysine by EzekielDiet.com Posted on Sep 22, 2021 Pauling's Vitamin C and Lysine dosage recommendations from his Unified Theory Lecture on Heart Disease. Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid. 1976;84B(5):280-284. A cerebrovascular event, or stroke, can be classified as hemorrhagic or ischemic. There is little evidence that the flavonoids in most commercial preparations increase the bioavailability or efficacy of vitamin C (187). Ascorbic Acid: Biochemistry and Biomedical Cell Biology. Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer--Norfolk prospective study. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. email:[emailprotected], Chlorophyll and Metallo-Chlorophyll Derivatives, Healthcare Professional Continuing Education. Pauling L. The immune system. Cochrane Database Syst Rev. (PubMed), 72. Barbara Delage, Ph.D. Johnston CS, Luo B. 1994;151(4):834-837. South Med J. (PubMed), 155. Collins R, Peto R, Armitage J. (PubMed), 102. Kook SY, Lee KM, Kim Y, et al. DeRitter E, Cohen N, Rubin SH. 1982;23:35-47. They demonstrated in guinea pigs, which do not internally produce vitamin C as most other mammals do, that lipoprotein-a take the place of ascorbate (vitamin C) in arterial walls, weakening them . Although only a minority of trials delivered vitamin C intravenously, this administration route appeared to be more effective at reducing the risk of atrial fibrillationpresumably due to higher plasma concentrations achieved (140). Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial.

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